607 College Avenue Pittsburgh, PA 15232
888-855-9763

Molecular Diagnostics

Make informed medical decisions quickly with detection for a broad range of pathogens and potential antibiotic resistance in 24 hours.

ABOUT PCR BASED RAPID LABORATORY TESTING

PCR (Polymerase Chain Reaction) is a valuable molecular technique performed in a high complexity laboratory often used to accurately analyze pathogens’ genetic material.

  • As a modern molecular biology lab, Personalized Genomics Laboratory utilizes real-time PCR for pathogen identification AND the quantification and detection of bacteria, viruses and antibiotic resistance.
  • PCR is 3-5x more sensitive than conventional culture techniques and allows PGL Laboratory to report results for both pathogen identification and antibiotic resistance within 12-24 hours of specimen’s lab arrival.

PCR provides genetic identification of each pathogen with an unequalled accuracy rate of 99.8%

The Front Line of Infection Prevention and Control & Antibiotic Stewardship

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Simple specimen collection and transport

•  Non-invasive swab specimen collection
•  Viable specimen not required
•  No special transport medium
•  Unaffected by temperature

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Immunocompromised patients benefit

•  Reduces unnecessary antibiotics administration, adverse events and costs
•  Tests for resistance genes that target antibiotic class
•  Decreases spread of acquired infections

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Real-time.

•  Rapid and accurate diagnosis: 24 hours after receipt by the laboratory vs. 1-3 weeks for culture and sensitivity
•  Strain typing often incorporated in initial procedure
•  Detects multiple pathogens in a single specimen

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Precise pathogen identification

•  Strain typing often incorporated in initial procedure
•  High specificity
•  More definitive diagnosis than antigen assays
•  CAP and CLIA accredited

The most common types of HAIs are:
  • urinary tract infections (UTIs)
  • surgical site infections.
  • gastroenteritis.
  • meningitis.
  • pneumonia.
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Number of Healthcare Associated Infections (HAIs) per year

Molecular UTI

Urinary Tract Infections were considered easy to target and treat since more than 70% of cases were caused by E.coli. UTIs are still one of the most commonly diagnosed illnesses in older adults and the #1 reason antibiotics are prescribed in Long Term Care Facilities.

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Bacteria

Acinetobacter baumannii
Citrobacter freundii
Enterobacter aerogenes
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Escherichia coli
Klebsiella pneumoniae
Proteus mirabilis
Proteus vulgaris
Pseudomonas aeruginosa
Staphylococcus aureus
Staphylococcus
saprophyticus
Streptococcus algalactiae

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Fungi

Candida albicans
Candida glabrata
Candida krusei
Candida parapsilosis
Candida tropicalis

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STIs

Atopobium vaginae
Bacteroides fragilis
Chlamydia trachomatis
Gardnerella vaginalis
Human Papillomavirus
(Strains 16 & 18)
Mobiluncus curtisii
Mobiluncus mulieris
Mycoplasma genitalium
Mycoplasma hominis
Neisseria gonorrhoeae
Prevotella bivia

Molecular Respiratory

Acute respiratory infection remains the leading cause of death amongst young, geriatric and immune-comprised patients. As an infectious disease that interferes with normal breathing, the urgency to provide these populations access to modern technology is essential to detect multiple pathogens simultaneously.

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Viruses

Adenovirus
Coronavirus 229E
Coronavirus HKU1
Coronavirus NL63
Coronavirus OC43
Enterovirus
Human Bocavirus
Human Metapneumovirus
Human Rhinovirus
Influenza A, AH1 & A H3
Influenza B
Parainfluenza 1, 2, 3 & 4
Respiratory Syncytial Virus A & B

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Bacteria

Acinetobacter baumannii
Bartonella henselae
Bordetella pertussis
Chlamydia pneumoniae
Gordonia bronchialis
Haemophilus influenzae
Klebsiella pneumoniae
Legionella pneumoniae
Moraxella catarrhalis
Mycobacterium avium
Mycobacterium kansakii
Mycobacterium tuberculosis
Mycoplasma pneumoniae
Neisseria meningitides
Staphylococcus aureus
Streptococcus pneumoniae
Streptococcus pyogens

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Fungi

Asperigillus niger
Asperigillus fumigatus
Asperigillus flavus
Asperigillus clavatus
Cryptococcus neoformans
Cladosporium herbarum
Penicillium chrysogenum

Molecular Gastro (GI)

Gastroenteritis Pathogens Unidentified with Conventional Treatments.
GI infections can be viral, bacterial or parasitic causing inflammation of the gastrointestinal tract. Treatment for patients with serious symptoms include antibiotics or other conventional techniques depending on the subsequent testing and even poor clinical outcomes. Traditional lab tests are also labor intensive and often lack the suitable sensitivity needed for effective results.

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Bacteria

Campylobacter jejuni
Campylobacter coli
Campylobacter upsaliensis
Clostridium difficile
Clostridium perfringens
Escherichia coli 0157: H7
Escherichia coli
(ETEC, EAEC & EPEC)
Helicobacter pylori
Plesiomonas shigelloides
Staphylococcus aureus
Salmonella
Shigella
Vibrio cholera
Vibrio parahaemolyticus
Vibrio vulnificus
Yersinia enterocolitica

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Parasites

Cryptosporidium hominis
Cryptosporidium parvum
Cyclospora cayetanensis
Entamoeba histolytica
Giardia duodenalis
Giardia intestinalis
Giardia lamblia

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Viruses

Adenovirus
Astrovirus
Norovirus
Rotavirus
Sapovirus

Molecular Wound

Our wound panels have the ability to enhance wound care specialists’ treatment plans and improve their patient outcomes. Wound care specialists have used PGL diagnostics molecular microbial diagnostic information to develop personalized medicine methods in wound care.

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Bacteria

Acinetobacter baumannii
Bacteroides fragilis
Clostridium perfringens
Corynebacterium
amycolatum
Corynebacterium striatum
Eikenella corrodens
Enterobacter aerogenes
Enterobacter cloacae
Enterococcus faecalis
Enterococcus faecium
Escherichia coli
Finegoldia magna
Klebsiella pneumoniae
Morganella morganii
Peptoniphilus
asaccharolyticus
Peptostreptococcus
anaerobius
Peptostreptococcus micros
Peptostreptococcus prevotii
Peptostreptococcus tetradiu
Porphyromonas
asaccharolytica
Prevotella loescheii
Prevotella melaninogenicus
Proteus mirabilis
Pseudomonas aeruginosa
Salmonella enterica
Serratia marcescens
Staphylococcus aureus
Staphylococcus epidermis
Streptococcus algalactiae
Streptococcus pneumoniae
Streptococcus pyogens

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Fungi

Candida albicans
Candida glabrata
Candida parapsilosis
Candida tropicalis
Candida krusel

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Antibiotic Stewardship Program

Education | Testing | Pharmacy | ASP Reporting

Education
Using the PGL ASP Education Platform, facilities will save time and money while earning CE credits toward their professional healthcare designation at no cost.

Infectious Disease Testing
The PGL diagnostic testing will answer quickly if a patient has a bacterial infection, identify the bacteria and recommend the proper antibiotic to use. A quick accurate answer prevents a costly long-term illness.

Pharmacy
As part of PGL infectious disease testing, a trained pharmacist performs a professional overread on each test to determine what medication therapy is best suited to that individual patient. The service is added at no additional cost.

ASP Reporting
Each month, a detailed ASP report will be provided to each facility detailing the patients tested, bacteria present and recommended medications. The report will be able to be handed to the state surveyors each year preventing costly penalties from SP at no additional cost.